Anti-Human CD172a/SIRPA Reference Antibody (GS 0189)
- Catalog number: BS12079
- Availability: In Stock
$370.00
- Ex Tax: $370.00
Description: Anti-Human CD172a/SIRPA Antibody (GS 0189) (BS12079) is a research-grade recombinant antibody targeting CD172. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG1
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: BIT,Signal-regulatoryproteinalpha-1,BrainIg-likemoleculewithtyrosine-basedactivationmotifs,MFR,SIRP,Sirp-alpha-1,Sirp-alpha-2,PTPNS1,SIRPA,SHPsubstrate1,CD172antigen-likefamilymemberA,Sirp-alpha-3,InhibitoryreceptorSHPS-1,Signal-regulatoryproteinalpha-3,CD172a,Tyrosine-proteinphosphatasenon-receptortypesubstrate1,MyD-1antigen,Bit,SHPS-1,Macrophagefusionreceptor,Signal-regulatoryproteinalpha-2,SHPS1,MYD1,p84
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: GS0189,FSI189
Background: Tyrosine-protein phosphatase non-receptor type substrate 1 (CD172a/SIRPA) is a ~54 kDa protein. Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin.
References:
1. Yao, M. et al. (2014) Journal of the American Society of Nephrology : JASN 25, 1171-86. PMID: 24511121
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG1
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: BIT,Signal-regulatoryproteinalpha-1,BrainIg-likemoleculewithtyrosine-basedactivationmotifs,MFR,SIRP,Sirp-alpha-1,Sirp-alpha-2,PTPNS1,SIRPA,SHPsubstrate1,CD172antigen-likefamilymemberA,Sirp-alpha-3,InhibitoryreceptorSHPS-1,Signal-regulatoryproteinalpha-3,CD172a,Tyrosine-proteinphosphatasenon-receptortypesubstrate1,MyD-1antigen,Bit,SHPS-1,Macrophagefusionreceptor,Signal-regulatoryproteinalpha-2,SHPS1,MYD1,p84
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: GS0189,FSI189
Background: Tyrosine-protein phosphatase non-receptor type substrate 1 (CD172a/SIRPA) is a ~54 kDa protein. Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin.
References:
1. Yao, M. et al. (2014) Journal of the American Society of Nephrology : JASN 25, 1171-86. PMID: 24511121
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
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SDS-PAGESDS-PAGE for Research Grade Anti-Human CD172a/SIRPA Antibody (GS 0189)
