Anti-Neisseria meningitidis fhbP/GNA1870/LP2086 Antibody (SAA2081)

Description: Anti-Neisseria meningitidis fhbP/GNA1870/LP2086 Antibody (SAA2081) [SAA2081] (RA14177) is a human monoclonal antibody detecting fhbP in ELISA.
Host species: Human
Isotype: IgG1, kappa
Species reactivity: Neisseria meningitidis serogroup B (strain MC58), Neisseria meningitidis
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: fhbP
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Factor H binding protein (FHBP) is a ~28 kDa protein. A bacterial surface lipoprotein that binds host (human) complement factor H (fH, gene CFH), binding contributes to the avoidance of complement-mediated lysis by N.meningitidis. Binding of fH to the bacteria surface is independent of bacterial sialic acid moieties. fH binding affinity is high enough that it may sequester plasma fH, depleting its circulating levels and de-regulating complement in the host (Probable). This protein induces high levels of bactericidal antibodies in mice.
References:
1. Schneider, MC. et al. (2006) Journal of immunology (Baltimore, Md. : 1950) 176, 7566-75. PMID: 16751403
2. Masignani, V. et al. (2003) The Journal of experimental medicine 197, 789-99. PMID: 12642606
3. Fletcher, LD. et al. (2004) Infection and immunity 72, 2088-100. PMID: 15039331
4. Giuliani, MM. et al. (2005) Infection and immunity 73, 1151-60. PMID: 15664958
5. Scarselli, M. et al. (2011) Science translational medicine 3, 91ra62. PMID: 21753121
6. Johnson, S. et al. (2012) PLoS pathogens 8, e1002981. PMID: 23133374
Note: For research use only.