Mouse Anti-Human BMP2 Antibody (Iv0058)
- Catalog number: RA14233
- Availability: In Stock
$196.00
- Ex Tax: $196.00
Description: Mouse Anti-Human BMP2 Antibody (Iv0058) [Iv0058] (RA14233) is a mouse monoclonal antibody detecting BMP-2 in ELISA, Neutralization. Suitable for Human.
Host species: Mouse
Isotype: IgG2a, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 0.88 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA, Neutralization
Target: BMP-2, BMP2A, Bone morphogenetic protein 2A, Bone morphogenetic protein 2, BMP2, BMP-2A
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Bone morphogenetic protein 2 (BMP2) is a ~44 kDa protein. Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes.
References:
1. Lavery, K. et al. (2008) The Journal of biological chemistry 283, 20948-58. PMID: 18436533
2. Tanaka, K. et al. (2014) Calcified tissue international 94, 454-64. PMID: 24362451
3. Seeherman, HJ. et al. (2019) Science translational medicine 11. PMID: 31019025
4. Wozney, JM. et al. (1988) Science (New York, N.Y.) 242, 1528-34. PMID: 3201241
5. Keller, S. et al. (2004) Nature structural & molecular biology 11, 481-8. PMID: 15064755
6. Weber, D. et al. (2007) BMC structural biology 7, 6. PMID: 17295905
7. Liu, F. et al. (1995) Molecular and cellular biology 15, 3479-86. PMID: 7791754
8. Wang, CY. et al. (2020) Blood 135, 453-456. PMID: 31800957
9. Tsukahara, S. et al. (2006) The Biochemical journal 398, 595-603. PMID: 16771708
Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Mouse Anti-Human BMP2 Antibody (Iv0058).
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Flow CytoMetryFlow-cytometry using PE anti-human BMP4 antibody. HepG-2 cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an PE anti-human BMP4 monoclonal antibody (Catalog: HY576023, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
