InVivoMAb Anti-Human ApoC3 Antibody (Iv0249)

Description: InVivoMAb Anti-Human ApoC3 Antibody (Iv0249) [Iv0249] (RA14371) is a human monoclonal antibody detecting Apolipoprotein C-III in ELISA, FuncS. Suitable for Human.
Host species: Human
Isotype: IgG1, kappa
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA, FuncS
Target: Apolipoprotein C-III, Apo-CIII, ApoC-III, Apolipoprotein C3, APOC3
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Apolipoprotein C-III (ApoC3) is a ~10 kDa protein. Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners.
References:
1. Chan, DC. et al. (2008) International journal of clinical practice 62, 799-809. PMID: 18201179
2. Yao, Z. et al. (2012) Current opinion in lipidology 23, 206-212. PMID: 22510806
3. Gangabadage, CS. et al. (2008) The Journal of biological chemistry 283, 17416-27. PMID: 18408013
Note: For research use only. Not suitable for clinical or therapeutic use.