Anti-Toxoplasma gondii SAG1/Major surface antigen p30 Antibody (SAA2154)

Description: Anti-Toxoplasma gondii SAG1/Major surface antigen p30 Antibody (SAA2154) [SAA2154] (RA14384) is a human monoclonal antibody detecting Major surface antigen p30 in ELISA. Suitable for Toxoplasma gondii.
Host species: Human
Isotype: IgG1
Species reactivity: Toxoplasma gondii
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: Major surface antigen p30
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Major surface antigen p30 (SAG1) is a ~34 kDa protein. Mediates binding to host cells and is especially important for parasite attachment and fitness in IFN-gamma/IFNG-stimulated host cells. May regulate binding between human S100A6 and vimentin (VIM) for cytoskeleton organization during the early stages of invasion into host cells. Promotes TNF secretion in host cells probably by enhancing binding between human VIM and PRKCQ and activating NF-kappa-B pathway. Promotes viability of host cells to satisfy the survival needs of parasites through the interaction with human RACK1.
References:
1. Robinson, SA. et al. (2004) Parasitology 128, 391-6. PMID: 15151144
2. Cohen, O. et al. (2025) Infection and immunity 93, e0001025. PMID: 40607979
3. Zhou, LJ. et al. (2021) iScience 24, 103514. PMID: 34950858
4. Wang, D. et al. (2024) Acta tropica 251, 107112. PMID: 38157925
Note: For research use only.