InVivoMAb Anti-HCMV/HHV-5 gB/Envelope glycoprotein B Antibody (8F9)

Description: InVivoMAb Anti-HCMV/HHV-5 gB/Envelope glycoprotein B Antibody (8F9) [8F9] (RA14441) is a human monoclonal antibody detecting Envelope glycoprotein B in ELISA, Neutralization.
Host species: Human
Isotype: IgG1
Species reactivity: Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA, Neutralization
Target: Envelope glycoprotein B, gB, gB, UL55
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Envelope glycoprotein B (gB) is a ~101 kDa protein. Envelope glycoprotein that plays a role in host cell entry, cell to-cell virus transmission, and fusion of infected cells. May be involved in the initial attachment via binding to heparan sulfate together with the gM/gN complex that binds heparin with higher affinity. Interacts with host integrin ITGB1, PDGFRA and EGFR that likely serve as postattachment entry receptors. Also participates in the fusion of viral and cellular membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.
Note: For research use only. Not suitable for clinical or therapeutic use.