Anti-Hantaan virus/HTNV GP Antibody (A5)

Description: Anti-Hantaan virus/HTNV GP Antibody (A5) [A5] (RA14453) is a human monoclonal antibody in ELISA.
Host species: Human
Isotype: IgG1
Species reactivity: Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus)
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA
Target: nan
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Envelopment polyprotein (GP/Envelope Glycoprotein Gc) is a ~126 kDa protein. Forms homotetramers with glycoprotein C at the surface of the virion. Attaches the virion to host cell receptors including integrin ITGAV/ITGB3. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. May also bind to host C1QBP for virus entry into the host cell. Mediates the assembly and budding of infectious virus particles through its interaction with the nucleocapsid protein and the viral genome.
References:
1. Raymond, T. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 1163-8. PMID: 1565712
2. Mou, DL. et al. (2006) Biochemical and biophysical research communications 339, 611-7. PMID: 16310165
3. Müller, A. et al. (2019) Virus research 267, 36-40. PMID: 31054291
4. Jin, M. et al. (2002) Virology 294, 60-9. PMID: 11886265
5. Choi, Y. et al. (2008) Virology 381, 178-83. PMID: 18834607
6. Wang, K. et al. (2019) Cell reports 27, 2075-2091.e5. PMID: 31091447
Note: For research use only.