InVivoMAb Anti-aPC/Activated protein C Antibody (C717)

Description: InVivoMAb Anti-aPC/Activated protein C Antibody (C717) [C717] (RA14510) is a mouse monoclonal antibody detecting Anticoagulant protein C in ELISA, Neutralization. Suitable for Human, Dog, and Rabbit.
Highlights:
• Multi-Species — Cross-reactive for translational research.
Host species: Mouse
Isotype: IgG2a
Species reactivity: Human, Dog, Rabbit
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA, Neutralization
Target: Anticoagulant protein C, Vitamin K-dependent protein C, Blood coagulation factor XIV, Autoprothrombin IIA, PROC
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Vitamin K-dependent protein C (aPC/Activated protein C) is a ~52 kDa protein. Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
References:
1. Kovács, KB. et al. (2015) Thrombosis research 135, 718-26. PMID: 25618265
2. Cao, Q. et al. (2025) Nature 639, 816-824. PMID: 39880037
3. Ding, Q. et al. (2015) Blood 125, 2428-34. PMID: 25651845
Note: For research use only. Not suitable for clinical or therapeutic use.