Dog Anti-RABV G/Glycoprotein Antibody (SAA2224)

Description: Dog Anti-RABV G/Glycoprotein Antibody (SAA2224) [SAA2224] (RA14568) is a dog monoclonal antibody detecting Glycoprotein in ELISA, Neutralization, WB. Suitable for Rabies virus (RABV).
Highlights:
• Multi-Application — Validated across multiple applications.
Host species: Dog
Isotype: IgG2, lambda
Species reactivity: Rabies virus (RABV)
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA, Neutralization, WB
Target: Glycoprotein, G
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Glycoprotein is a ~58 kDa protein. Attaches the virus to host cellular receptor, inducing endocytosis of the virion by using different host proteins including TFRC, GRM2 and ITGB1. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.
Note: For research use only.