Anti-Human KDM2A IP Antibody (SAA0201)

Description: Anti-Human KDM2A IP Antibody (SAA0201) [SAA0201] (RA14596) is a mouse monoclonal antibody detecting KDM2A in ELISA, IF, IP. Suitable for Human.
Highlights:
• Multi-Application — Validated across multiple applications.
Host species: Mouse
Isotype: IgG1
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA, IF, IP
Target: KDM2A, CXXC-type zinc finger protein 8, FBXL11, JHDM1A, FBL7, KIAA1004, F-box protein FBL7, Lysine-specific demethylase 2A, FBL11, [Histone-H3]-lysine-36 demethylase 1A, F-box protein Lilina, JmjC domain-containing histone demethylation protein 1A, F-box/LRR-repeat protein 11, CXXC8, F-box and leucine-rich repeat protein 11
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Lysine-specific demethylase 2A (KDM2A) is a ~132 kDa protein. Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere.
References:
1. Reischl, S. et al. (2015) Journal of biological rhythms 30, 291-301. PMID: 26037310
Note: For research use only.