Anti-Human KDM6B IP Antibody (SAA0207)

Description: Anti-Human KDM6B IP Antibody (SAA0207) [SAA0207] (RA14602) is a mouse monoclonal antibody detecting KDM6B in ELISA, IF, IP. Suitable for Human.
Highlights:
• Multi-Application — Validated across multiple applications.
Host species: Mouse
Isotype: IgG2a
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1.93 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA, IF, IP
Target: JMJD3, [histone H3]-trimethyl-L-lysine(27) demethylase 6B, Jumonji domain-containing protein 3, KDM6B, JmjC domain-containing protein 3, KIAA0346, Lysine demethylase 6B, Lysine-specific demethylase 6B
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Lysine-specific demethylase 6B (KDM6B) is a ~176 kDa protein. Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex.
References:
1. Agger, K. et al. (2007) Nature 449, 731-4. PMID: 17713478
2. De Santa, F. et al. (2007) Cell 130, 1083-94. PMID: 17825402
3. Lan, F. et al. (2007) Nature 449, 689-94. PMID: 17851529
4. Hong, S. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 18439-44. PMID: 18003914
Note: For research use only.