Anti-Human L3MBTL3 IP Antibody (SAA0209)

Description: Anti-Human L3MBTL3 IP Antibody (SAA0209) [SAA0209] (RA14604) is a mouse monoclonal antibody detecting L3MBTL3 in ELISA, IF, IP, IP-MS. Suitable for Human.
Highlights:
• Multi-Application — Validated across multiple applications.
Host species: Mouse
Isotype: IgG1
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA, IF, IP, IP-MS
Target: Lethal(3)malignant brain tumor-like protein 3, H-l(3)mbt-like protein 3, KIAA1798, L3MBTL3, L3mbt-like 3, MBT-1, L(3)mbt-like protein 3, MBT1
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) is a ~88 kDa protein. Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression. It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation. Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins. Required for normal maturation of myeloid progenitor cells.
References:
1. Xu, T. et al. (2017) The EMBO journal 36, 3232-3249. PMID: 29030483
2. Leng, F. et al. (2018) Nature communications 9, 1641. PMID: 29691401
3. Zhang, C. et al. (2019) The Journal of biological chemistry 294, 476-489. PMID: 30442713
Note: For research use only.