Anti-Human SETD7 IP Antibody (SAA0223)

Description: Anti-Human SETD7 IP Antibody (SAA0223) [SAA0223] (RA14618) is a mouse monoclonal antibody detecting SETD7 in ELISA, IF, IP. Suitable for Human.
Highlights:
• Multi-Application — Validated across multiple applications.
Host species: Mouse
Isotype: IgG2a
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA, IF, IP
Target: Lysine N-methyltransferase 7, SET9, SET7/9, Histone H3-K4 methyltransferase SETD7, SET7, SET domain-containing protein 7, SETD7, H3-K4-HMTase SETD7, KIAA1717, Histone-lysine N-methyltransferase SETD7, KMT7
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Histone-lysine N-methyltransferase SETD7 is a ~40 kDa protein. Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Also has methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins.
References:
1. Wang, H. et al. (2001) Molecular cell 8, 1207-17. PMID: 11779497
2. Nishioka, K. et al. (2002) Genes & development 16, 479-89. PMID: 1185041
3. Xiao, B. et al. (2003) Nature 421, 652-6. PMID: 12540855
4. Martens, JH. et al. (2003) Molecular and cellular biology 23, 1808-16. PMID: 12588998
5. Francis, J. et al. (2005) The Journal of biological chemistry 280, 36244-53. PMID: 16141209
6. Xiao, Y. et al. (2022) Bone research 10, 19. PMID: 35210392
Note: For research use only.