Anti-Human TDRD3 IP Antibody (SAA0234)

Description: Anti-Human TDRD3 IP Antibody (SAA0234) [SAA0234] (RA14629) is a mouse monoclonal antibody detecting TDRD3 in ELISA, IF, IP. Suitable for Human.
Highlights:
• Multi-Application — Validated across multiple applications.
Host species: Mouse
Isotype: IgG
Species reactivity: Human
Form: Liquid
Storage buffer: 0.01M PBS, pH 7.4.
Concentration: 1 mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: ELISA, IF, IP
Target: TDRD3, Tudor domain-containing protein 3
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: Please contact with the lab for this information.
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Tudor domain-containing protein 3 (TDRD3) is a ~73 kDa protein. Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1.
References:
1. Côté, J. et al. (2005) The Journal of biological chemistry 280, 28476-83. PMID: 15955813
2. Yang, Y. et al. (2010) Molecular cell 40, 1016-23. PMID: 21172665
3. Deater, M. et al. (2022) PLoS pathogens 18, e1010249. PMID: 35085371
Note: For research use only.