Anti-Human CD371/CLEC12A Reference Antibody (H6e7)
- Catalog number: BS12173
- Availability: In Stock
$370.00
- Ex Tax: $370.00
Description: Anti-Human CD371/CLEC12A Antibody (H6e7) (BS12173) is a research-grade recombinant antibody targeting CD371. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG1
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: CLEC12A,DCAL2,Dendriticcell-associatedlectin2,CLL-1,MyeloidinhibitoryC-typelectin-likereceptor,C-typelectindomainfamily12memberA,CLL1,DCAL-2,C-typelectin-likemolecule1,MICL,CD371
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: C-type lectin domain family 12 member A (CD371/CLEC12A) is a ~30 kDa protein. Myeloid inhibitory C-type lectin receptor that acts as a negative regulator of myeloid cell activation. Myeloid cell inhibition is required to limit proinflammatory pathways and protect against excessive inflammation. Specifically recognizes and binds various structures, such as neutrophil extracellular traps (NETs) or monosodium urate crystals. Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid. Ligand-binding induces phosphorylation of its ITIM motif, followed by recruitment of tyrosine-protein phosphatases PTPN6 and PTPN11, which counteract tyrosine-protein kinase SYK, thereby preventing myeloid cell activation.
References:
1. Marshall, AS. et al. (2004) The Journal of biological chemistry 279, 14792-802. PMID: 1473928
2. Han, Y. et al. (2004) Blood 104, 2858-66. PMID: 15238421
3. Chen, CH. et al. (2006) Blood 107, 1459-67. PMID: 16239426
4. Paré, G. et al. (2021) Frontiers in immunology 12, 650808. PMID: 34234773
5. Tang, H. et al. (2024) The Journal of biological chemistry 300, 105765. PMID: 38367667
6. Mori, S. et al. (2024) International immunology 36, 279-290. PMID: 38386511
7. Malamud, M. et al. (2024) Nature 633, 442-450. PMID: 39143217
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG1
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: CLEC12A,DCAL2,Dendriticcell-associatedlectin2,CLL-1,MyeloidinhibitoryC-typelectin-likereceptor,C-typelectindomainfamily12memberA,CLL1,DCAL-2,C-typelectin-likemolecule1,MICL,CD371
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: C-type lectin domain family 12 member A (CD371/CLEC12A) is a ~30 kDa protein. Myeloid inhibitory C-type lectin receptor that acts as a negative regulator of myeloid cell activation. Myeloid cell inhibition is required to limit proinflammatory pathways and protect against excessive inflammation. Specifically recognizes and binds various structures, such as neutrophil extracellular traps (NETs) or monosodium urate crystals. Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid. Ligand-binding induces phosphorylation of its ITIM motif, followed by recruitment of tyrosine-protein phosphatases PTPN6 and PTPN11, which counteract tyrosine-protein kinase SYK, thereby preventing myeloid cell activation.
References:
1. Marshall, AS. et al. (2004) The Journal of biological chemistry 279, 14792-802. PMID: 1473928
2. Han, Y. et al. (2004) Blood 104, 2858-66. PMID: 15238421
3. Chen, CH. et al. (2006) Blood 107, 1459-67. PMID: 16239426
4. Paré, G. et al. (2021) Frontiers in immunology 12, 650808. PMID: 34234773
5. Tang, H. et al. (2024) The Journal of biological chemistry 300, 105765. PMID: 38367667
6. Mori, S. et al. (2024) International immunology 36, 279-290. PMID: 38386511
7. Malamud, M. et al. (2024) Nature 633, 442-450. PMID: 39143217
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
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SDS-PAGESDS-PAGE for Research Grade Anti-Human CD337/NCR3 Antibody (BGA-1833)
