Anti-Human CD119/IFNGR1 Antibody (SAA0044)
- Catalog number: FC10043
- Availability: In Stock
$191.00
- Ex Tax: $191.00
- Description: Anti-Human CD119/IFNGR1 Antibody (SAA0044) [SAA0044] (FC10043) is a mouse monoclonal antibody detecting IFNGR1 in FCM. Suitable for Human.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications. - Model: HB990107
- Name: Anti-Human CD119/IFNGR1 Antibody (SAA0044)
- Host species: Mouse
- Isotype: IgG1, kappa
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4.
- Concentration: 1 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: FCM
- Target: IFN-gamma-R1, Interferon gamma receptor 1, CDw119, Interferon gamma receptor alpha-chain, IFN-gamma receptor 1, IFNGR1, IFN-gamma-R-alpha, CD119
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Interferon gamma receptor 1 (CD119/IFNGR1) is a ~54 kDa protein. Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription.
References:
1. van de Wetering, D. et al. (2010) Molecular immunology 47, 1023-30. PMID: 2001555
2. Thiel, DJ. et al. (2000) Structure (London, England : 1993) 8, 927-36. PMID: 1098646
3. Aguet, M. et al. (1988) Cell 55, 273-80. PMID: 2971451
4. Sakatsume, M. et al. (1995) The Journal of biological chemistry 270, 17528-34. PMID: 7615558
5. Walter, MR. et al. (1995) Nature 376, 230-5. PMID: 7617032
6. Kotenko, SV. et al. (1995) The Journal of biological chemistry 270, 20915-21. PMID: 7673114
7. Londino, JD. et al. (2017) The Biochemical journal 474, 3543-3557. PMID: 28883123 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Anti-Human CD119/IFNGR1 Antibody (SAA0044)
