Anti-Human IL1RL1/ST2 Antibody (SAA0139)
- Catalog number: FC10082
- Availability: In Stock
$191.00
- Ex Tax: $191.00
- Description: Anti-Human IL1RL1/ST2 Antibody (SAA0139) [SAA0139] (FC10082) is a human monoclonal antibody detecting Protein ST2 in FCM. Suitable for Human.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications. - Model: HX139207
- Name: Anti-Human IL1RL1/ST2 Antibody (SAA0139)
- Host species: Human
- Isotype: IgG1
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4.
- Concentration: 1 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: FCM
- Target: T1, DER4, Interleukin-1 receptor-like 1, ST2, IL1RL1, Protein ST2
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Interleukin-1 receptor-like 1 (IL1RL1/ST2) is a ~63 kDa protein. Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages.
References:
1. Yi, XM. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2116279119. PMID: 35238669
2. Schmitz, J. et al. (2005) Immunity 23, 479-90. PMID: 16286016 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Anti-Human IL1RL1/ST2 Antibody (SAA0139)
