Anti-Human GPC3 Antibody (SAA0134)
- Catalog number: FC10099
- Availability: In Stock
$191.00
- Ex Tax: $191.00
- Description: Anti-Human GPC3 Antibody (SAA0134) [SAA0134] (FC10099) is a human monoclonal antibody detecting GPC3 in ELISA, FCM, WB. Suitable for Human.
Highlights:
• Multi-Application — Validated across multiple applications.
• Flow Cytometry — Validated for flow cytometry applications. - Model: HW310107
- Name: Anti-Human GPC3 Antibody (SAA0134)
- Host species: Human
- Isotype: IgG1, kappa
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4.
- Concentration: 1.1 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: ELISA, FCM, WB
- Target: GPC3, MXR7, GTR2-2, Glypican-3, Intestinal protein OCI-5, OCI5
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Glypican-3 (GPC3/Glypican 3) is a ~65 kDa protein. Cell surface proteoglycan. Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins. Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation. Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands. Positively regulates the non-canonical Wnt signaling pathway.
References:
1. De Cat, B. et al. (2003) The Journal of cell biology 163, 625-35. PMID: 14610063
2. Capurro, MI. et al. (2005) The Journal of biological chemistry 280, 41201-6. PMID: 16227623
3. Capurro, M. et al. (2014) Journal of cell science 127, 1565-75. PMID: 24496449
4. Davoodi, J. et al. (2007) Proteomics 7, 2300-10. PMID: 17549790 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Anti-Human GPC3 Antibody (SAA0134)
Datasheet
