Anti-Human FOLR1 Antibody (SAA0118)
- Catalog number: FC10108
- Availability: In Stock
$191.00
- Ex Tax: $191.00
- Description: Anti-Human FOLR1 Antibody (SAA0118) [SAA0118] (FC10108) is a human monoclonal antibody detecting FOLR1 in FCM. Suitable for Human.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications. - Model: HB825207
- Name: Anti-Human FOLR1 Antibody (SAA0118)
- Host species: Human
- Isotype: IgG1, kappa
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 0.02% Tween 80.
- Concentration: 2.75 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: FCM
- Target: Folate receptor alpha, FOLR, FOLR1, Adult folate-binding protein, Folate receptor 1, FR-alpha, KB cells FBP, FBP, Ovarian tumor-associated antigen MOv18, Folate receptor, adult
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Folate receptor alpha (FOLR1) is a ~29 kDa protein. Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. FOLR1 is the therapeutic target of mirvetuximab soravtansine (Elahere).
References:
1. Zhao, R. et al. (2009) The Journal of biological chemistry 284, 4267-74. PMID: 19074442
2. Chen, C. et al. (2013) Nature 500, 486-9. PMID: 23851396
3. Wibowo, AS. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 15180-8. PMID: 23934049
4. Lacey, SW. et al. (1989) The Journal of clinical investigation 84, 715-20. PMID: 2527252
5. Orr, RB. et al. (1994) Cancer research 54, 3905-11. PMID: 8033114
6. Rijnboutt, S. et al. (1996) The Journal of cell biology 132, 35-47. PMID: 8567728 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Anti-Human FOLR1 Antibody (SAA0118)
Datasheet
