Anti-Human CD126/IL6R/IL-6RA Antibody (SAA0049)
- Catalog number: FC10142
- Availability: In Stock
$191.00
- Ex Tax: $191.00
- Description: Anti-Human CD126/IL6R/IL-6RA Antibody (SAA0049) [SAA0049] (FC10142) is a human monoclonal antibody detecting IL-6RA in FCM. Suitable for Human.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications. - Model: HY583207
- Name: Anti-Human CD126/IL6R/IL-6RA Antibody (SAA0049)
- Host species: Human
- Isotype: IgG2, kappa
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4.
- Concentration: 1 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: FCM
- Target: sIL6R, Interleukin-6 receptor subunit alpha, CD126, IL-6R 1, IL-6R subunit alpha, Membrane glycoprotein 80, gp80, IL6R, IL-6RA, IL-6 receptor subunit alpha, IL-6R-alpha
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Interleukin-6 receptor subunit alpha (CD126/IL6R) is a ~51 kDa protein. Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system.
References:
1. Larsen, JV. et al. (2017) Molecular and cellular biology 37. PMID: 28265003
2. Kang, S. et al. (2019) Immunity 50, 1007-1023. PMID: 30995492
3. Spencer, S. et al. (2019) The Journal of experimental medicine 216, 1986-1998. PMID: 31235509 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Anti-Human CD126/IL6R/IL-6RA Antibody (SAA0049).
