Anti-Human CD121a/IL1R1 Reference Antibody (AMG108)
- Catalog number: BS12188
- Availability: In Stock
$370.00
- Ex Tax: $370.00
Description: Anti-Human CD121a/IL1R1 Antibody (AMG108) (BS12188) is a research-grade recombinant antibody targeting CD121. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG1
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: IL-1RT1,IL-1R-alpha,mIL-1R1,CD121a,IL-1R-1,sIL-1RI,IL1RT1,IL1R1,sIL-1R1,IL1R,CD121antigen-likefamilymemberA,Interleukin-1receptortypeI,Interleukin-1receptoralpha,mIL-1RI,IL1RA,IL-1RT-1,Interleukin-1receptortype1,p80
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: AMG108,AMG108,AMG-108
Background: Interleukin-1 receptor type 1 (CD121a/IL1R1) is a ~65 kDa protein. Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells.
References:
1. Mosley, B. et al. (1987) The Journal of biological chemistry 262, 2941-4. PMID: 2950091
2. Wang, Y. et al. (2023) Immunity 56, 1485-1501.e7. PMID: 3731556
3. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG1
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: IL-1RT1,IL-1R-alpha,mIL-1R1,CD121a,IL-1R-1,sIL-1RI,IL1RT1,IL1R1,sIL-1R1,IL1R,CD121antigen-likefamilymemberA,Interleukin-1receptortypeI,Interleukin-1receptoralpha,mIL-1RI,IL1RA,IL-1RT-1,Interleukin-1receptortype1,p80
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: AMG108,AMG108,AMG-108
Background: Interleukin-1 receptor type 1 (CD121a/IL1R1) is a ~65 kDa protein. Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells.
References:
1. Mosley, B. et al. (1987) The Journal of biological chemistry 262, 2941-4. PMID: 2950091
2. Wang, Y. et al. (2023) Immunity 56, 1485-1501.e7. PMID: 3731556
3. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
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SDS-PAGESDS-PAGE for Research Grade Anti-Human CD121a/IL1R1 Antibody (AMG108)
