Anti-Human CD239/BCAM Antibody (C7#)
- Catalog number: FC10252
- Availability: In Stock
$191.00
- Ex Tax: $191.00
- Description: Anti-Human CD239/BCAM Antibody (C7#) [C7#] (FC10252) is a mouse monoclonal antibody detecting CD239 in FCM, WB. Suitable for Human.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications. - Model: HW406107
- Name: Anti-Human CD239/BCAM Antibody (C7#)
- Host species: Mouse
- Isotype: IgG1, kappa
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4.
- Concentration: 1 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: FCM
- Target: Basal cell adhesion molecule, LU, MSK19, Auberger B antigen, CD239, Lutheran blood group glycoprotein, Lutheran antigen, F8/G253 antigen, B-CAM cell surface glycoprotein, BCAM
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Basal cell adhesion molecule (CD239/BCAM) is a ~67 kDa protein. Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion. Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction. Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion. Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR.
References:
1. Udani, M. et al. (1998) The Journal of clinical investigation 101, 2550-8. PMID: 9616226
2. Guadall, A. et al. (2019) The Journal of biological chemistry 294, 14911-14921. PMID: 31413112
3. El Nemer, W. et al. (2007) Blood 109, 3544-51. PMID: 17158232
4. Gauthier, E. et al. (2005) The Journal of biological chemistry 280, 30055-62. PMID: 15975931
5. De Grandis, M. et al. (2013) Blood 121, 658-65. PMID: 23160466 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Anti-Human CD239/BCAM Antibody (C7#)
Datasheet
