Anti-Human CD243/P-Glycoprotein Antibody (C219)
- Catalog number: FC10257
- Availability: In Stock
$191.00
- Ex Tax: $191.00
- Description: Anti-Human CD243/P-Glycoprotein Antibody (C219) [C219] (FC10257) is a mouse monoclonal antibody detecting P-glycoprotein 1 in FCM, WB. Suitable for Human.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications. - Model: HY466107
- Name: Anti-Human CD243/P-Glycoprotein Antibody (C219)
- Host species: Mouse
- Isotype: IgG1, kappa
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4.
- Concentration: 1 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: FCM, WB
- Target: Phospholipid transporter ABCB1, MDR1, CD243, ATP-binding cassette sub-family B member 1, ABCB1, Multidrug resistance protein 1, P-glycoprotein 1, ATP-dependent translocase ABCB1, PGY1, P-Glycoprotein, P Glycoprotein
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: ATP-dependent translocase ABCB1 (CD243) is a ~141 kDa protein. Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
References:
1. Choi, KH. et al. (1988) Cell 53, 519-29. PMID: 289724
2. Masud, SN. et al. (2022) Nature chemical biology 18, 1370-1379. PMID: 35970996
3. van Helvoort, A. et al. (1996) Cell 87, 507-17. PMID: 8898203
4. Chen, G. et al. (1997) The Journal of biological chemistry 272, 5974-82. PMID: 9038218
5. Shafik, SH. et al. (2022) PLoS biology 20, e3001616. PMID: 35507548 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Anti-Human CD243/P-Glycoprotein Antibody (C219)
