Anti-Human CD248 Antibody (SAA0182)
- Catalog number: FC10261
- Availability: In Stock
$191.00
- Ex Tax: $191.00
- Description: Anti-Human CD248 Antibody (SAA0182) [SAA0182] (FC10261) is a human monoclonal antibody detecting CD248 in FCM. Suitable for Human.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications. - Model: HV681107
- Name: Anti-Human CD248 Antibody (SAA0182)
- Host species: Human
- Isotype: IgG1, kappa
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4.
- Concentration: 1 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: FCM
- Target: Endosialin, TEM1, CD164L1, Tumor endothelial marker 1, CD248
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Endosialin (CD248) is a ~80 kDa protein. Cell surface glycoprotein involved in various biological processes including angiogenesis, immune response modulation, and tissue remodeling and repair. Participates in pericyte proliferation through positive modulation of the PDGF receptor signaling pathway. Acts as a scaffold for factor X, triggering allosteric changes and the spatial re-alignment of factor X with the TF-factor VIIa complex, thereby enhancing coagulation activation. Modulates the insulin signaling pathway by interacting with insulin receptor/INSR and by diminishing its capacity to be autophosphorylated in response to insulin. Also regulates LPS-induced inflammatory response in macrophages by favoring the production of proinflammatory cytokines.
References:
1. Tomkowicz, B. et al. (2010) Cancer biology & therapy 9, 908-15. PMID: 20484976
2. Hardie, DL. et al. (2011) Immunology 133, 288-95. PMID: 21466550 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Anti-Human CD248 Antibody (SAA0182)
Datasheet
