Anti-Human CD278/ICOS Antibody (SAA0091)
- Catalog number: FC10290
- Availability: In Stock
$191.00
- Ex Tax: $191.00
- Description: Anti-Human CD278/ICOS Antibody (SAA0091) [SAA0091] (FC10290) is a human monoclonal antibody detecting CD278 in FCM. Suitable for Human.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications. - Model: HV702107
- Name: Anti-Human CD278/ICOS Antibody (SAA0091)
- Host species: Human
- Isotype: IgG1, kappa
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4.
- Concentration: 1 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: FCM
- Target: CD278, ICOS, Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, AILIM
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Inducible T-cell costimulator (CD278/ICOS) is a ~22 kDa protein. Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response. Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Also acts as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection. Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling. In addition, activates PI3K signaling pathways independently of calcium flux.
References:
1. Hutloff, A. et al. (1999) Nature 397, 263-6. PMID: 9930702
2. Rujas, E. et al. (2020) Nature communications 11, 5066. PMID: 33033255
3. Pedros, C. et al. (2016) Nature immunology 17, 825-33. PMID: 27135603
4. Wan, Z. et al. (2020) Cellular & molecular immunology 17, 143-152. PMID: 30523347 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Anti-Human CD278/ICOS Antibody (SAA0091)
