Anti-Human CD304/NRP1 Antibody (SAA0097)
- Catalog number: FC10309
- Availability: In Stock
$191.00
- Ex Tax: $191.00
- Description: Anti-Human CD304/NRP1 Antibody (SAA0097) [SAA0097] (FC10309) is a human monoclonal antibody detecting CD304 in FCM. Suitable for Human.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications. - Model: HT070107
- Name: Anti-Human CD304/NRP1 Antibody (SAA0097)
- Host species: Human
- Isotype: IgG1, kappa
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4.
- Concentration: 1 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: FCM
- Target: NRP1, Neuropilin-1, VEGF165R, NRP, CD304, Vascular endothelial cell growth factor 165 receptor
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Neuropilin-1 (CD304/NRP1) is a ~103 kDa protein. Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis.
References:
1. Gagnon, ML. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 2573-8. PMID: 1068888
2. He, Z. et al. (1997) Cell 90, 739-51. PMID: 9288753
3. Soker, S. et al. (1998) Cell 92, 735-45. PMID: 952925
4. Teesalu, T. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 16157-62. PMID: 19805273
5. Issitt, T. et al. (2019) iScience 11, 205-223. PMID: 30623799 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Anti-Human CD304/NRP1 Antibody (SAA0097)
