Anti-Human CD334/FGFR4 Antibody (U3-17846J6Ye)
- Catalog number: FC10330
- Availability: In Stock
$191.00
- Ex Tax: $191.00
- Description: Anti-Human CD334/FGFR4 Antibody (U3-17846J6Ye) [U3-17846J6Ye] (FC10330) is a human monoclonal antibody detecting FGFR4 in FCM. Suitable for Human.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications. - Model: HB856107
- Name: Anti-Human CD334/FGFR4 Antibody (U3-17846J6Ye)
- Host species: Mouse
- Isotype: IgG1, kappa
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4.
- Concentration: 1 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: FCM
- Target: FGFR4, Fibroblast growth factor receptor 4, TKF, FGFR-4, JTK2, CD334
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Fibroblast growth factor receptor 4 (CD334/FGFR4) is a ~87 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.
- Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-CD334/FGFR4 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD334/FGFR4 (Catalog No: PH13634)
Lane 2: negative control
