Anti-Human CD69 Antibody (SAA0031)
- Catalog number: FC10420
- Availability: In Stock
$196.00
- Ex Tax: $196.00
- Description: Anti-Human CD69 Antibody (SAA0031) [SAA0031] (FC10420) is a mouse monoclonal antibody detecting CD69 in FCM. Suitable for Human.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications. - Model: HC273107
- Name: Anti-Human CD69 Antibody (SAA0031)
- Host species: Mouse
- Isotype: IgG1
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4.
- Concentration: 1 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: FCM
- Target: AIM, CD69, C-type lectin domain family 2 member C, Early T-cell activation antigen p60, BL-AC/P26, GP32/28, MLR-3, Early activation antigen CD69, Leukocyte surface antigen Leu-23, CLEC2C, EA1, Activation inducer molecule
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Early activation antigen CD69 is a ~22 kDa protein. Transmembrane protein expressed mainly on T-cells resident in mucosa that plays an essential role in immune cell homeostasis. Rapidly expressed on the surface of platelets, T-lymphocytes and NK cells upon activation by various stimuli, such as antigen recognition or cytokine signaling, stimulates different signaling pathways in different cell types. Negatively regulates Th17 cell differentiation through its carbohydrate dependent interaction with galectin-1/LGALS1 present on immature dendritic cells. Association of CD69 cytoplasmic tail with the JAK3/STAT5 signaling pathway regulates the transcription of RORgamma/RORC and, consequently, differentiation toward the Th17 lineage. Also acts via the S100A8/S100A9 complex present on peripheral blood mononuclear cells to promote the conversion of naive CD4 T-cells into regulatory T-cells.
References:
1. de la Fuente, H. et al. (2014) Molecular and cellular biology 34, 2479-87. PMID: 24752896
2. Lin, CR. et al. (2015) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 29, 5006-17. PMID: 26296369
3. Jiménez-Fernández, M. et al. (2022) Cellular and molecular life sciences : CMLS 79, 468. PMID: 35930205
4. Jiang, Y. et al. (2021) Clinical and translational medicine 11, e563. PMID: 34841721
5. Chen, H. et al. (2023) eLife 12. PMID: 37039481 - Note: For research use only.
Images
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SEC-HPLCSEC-HPLC detection for Anti-Human CD69 Antibody (ABS2045).
Datasheet
