Anti-Mouse CD47/MER6 Antibody (A4)
- Catalog number: FC10467
- Availability: In Stock
$196.00
- Ex Tax: $196.00
- Description: Anti-Mouse CD47/MER6 Antibody (A4) [A4] (FC10467) is a mouse monoclonal antibody detecting CD47 in FCM. Suitable for Mouse.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications. - Model: MC359107
- Name: Anti-Mouse CD47/MER6 Antibody (A4)
- Host species: Mouse
- Isotype: VHH-mFc
- Conjugation: Unconjugated
- Species reactivity: Mouse
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4.
- Concentration: 1 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: FCM
- Target: Leukocyte surface antigen CD47, Integrin-associated protein, IAP, CD47
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Leukocyte surface antigen CD47 (MER6) is a ~33 kDa protein. Adhesive protein that mediates cell-to-cell interactions. Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins. Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation. Plays a role in modulating pulmonary endothelin EDN1 signaling. Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure. CD47 is the therapeutic target of magrolimab (clinical).
References:
1. Bauer, EM. et al. (2010) Cardiovascular research 88, 471-81. PMID: 20610415
2. Kaur, S. et al. (2013) Scientific reports 3, 1673. PMID: 23591719
3. Rogers, NM. et al. (2017) Cardiovascular research 113, 15-29. PMID: 27742621
4. Manna, PP. et al. (2005) The Journal of biological chemistry 280, 29637-44. PMID: 15917238
5. Ghimire, K. et al. (2020) Cells 9. PMID: 32679764
6. Isenberg, JS. et al. (2008) Annals of surgery 247, 180-90. PMID: 18156939
7. Oldenborg, PA. et al. (2000) Science (New York, N.Y.) 288, 2051-4. PMID: 10856220 - Note: For research use only.
Images
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Western blotWestern blot analysis was performed using anti-CD47/IAP monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant mouse CD47/IAP (Catalog No: PM10295)
Lane 2: negative control
Datasheet
