Anti-Mouse CD71/TFRC Antibody (8D3)
- Catalog number: FC10594
- Availability: In Stock
$196.00
- Ex Tax: $196.00
- Description: Anti-Mouse CD71/TFRC Antibody (8D3) [8D3] (FC10594) is a rat monoclonal antibody detecting CD71 in FCM, FuncS, ICC, IF, IHC, IHC-Fr. Suitable for Mouse.
Highlights:
• Multi-Application — Validated across multiple applications.
• Flow Cytometry — Validated for flow cytometry applications. - Model: MY036307
- Name: Anti-Mouse CD71/TFRC Antibody (8D3)
- Host species: Rat
- Isotype: IgG2a, kappa
- Conjugation: Unconjugated
- Species reactivity: Mouse
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4.
- Concentration: 1 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: FCM, FuncS, ICC, IF, IHC, IHC-Fr
- Target: Transferrin receptor protein 1, TfR1, T9, Trfr, p90, CD71, TFRC, TfR, sTfR, TR
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Transferrin receptor protein 1 (CD71/TFRC) is a ~85 kDa protein. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Upon stimulation, positively regulates T and B cell proliferation through iron uptake.
References:
1. Jabara, HH. et al. (2016) Nature genetics 48, 74-8. PMID: 2664224
2. Yang, J. et al. (2024) The Journal of clinical investigation 134. PMID: 38625739 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Anti-Mouse CD71/TFRC Antibody (8D3)
Datasheet
