Anti-Mouse CD156b/ADAM17 Antibody (A12)
- Catalog number: FC10611
- Availability: In Stock
$191.00
- Ex Tax: $191.00
- Description: Anti-Mouse CD156b/ADAM17 Antibody (A12) [A12] (FC10611) is a rat monoclonal antibody detecting CD156b in ELISA, FCM. Suitable for Human and Mouse.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications. - Model: MX200107
- Name: Anti-Mouse CD156b/ADAM17 Antibody (A12)
- Host species: Rat
- Isotype: IgG1, kappa
- Conjugation: Unconjugated
- Species reactivity: Human, Mouse
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4.
- Concentration: 0.65 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: ELISA, FCM
- Target: Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17, TNF-alpha convertase, TNF-alpha-converting enzyme, CD156b, Adam17, Tace
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Disintegrin and metalloproteinase domain-containing protein 17 (CD156b/ADAM17) is a ~93 kDa protein. Cleaves the membrane-bound precursor of TNF to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Plays a role in the proteolytic processing of ACE2. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called notch extracellular truncation (NEXT).
References:
1. Reddy, P. et al. (2000) The Journal of biological chemistry 275, 14608-14. PMID: 10799547
2. Zhang, Y. et al. (2000) Endocrinology 141, 4342-8. PMID: 11108241
3. Brou, C. et al. (2000) Molecular cell 5, 207-16. PMID: 10882063
4. Bergmeier, W. et al. (2003) Blood 102, 4229-35. PMID: 12907434
5. Li, N. et al. (2007) The EMBO journal 26, 494-504. PMID: 17245433 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Anti-Mouse CD156b/ADAM17 Antibody (A12)
