Anti-Human DSG2 Antibody (3D3)
- Catalog number: FC10682
- Availability: In Stock
$196.00
- Ex Tax: $196.00
- Description: Anti-Human DSG2 Antibody (3D3) [3D3] (FC10682) is a mouse monoclonal antibody detecting DSG2 in Blocking, ELISA, FCM, WB. Suitable for Human.
Highlights:
• Multi-Application — Validated across multiple applications.
• Flow Cytometry — Validated for flow cytometry applications. - Model: HC461107
- Name: Anti-Human DSG2 Antibody (3D3)
- Host species: Mouse
- Isotype: IgG2a, kappa
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 0.09% Sodium azide.
- Concentration: 1 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: Blocking, ELISA, FCM, WB
- Target: CDHF5, HDGC, Desmoglein-2, DSG2, Cadherin family member 5
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Desmoglein-2 (DSG2) is a ~122 kDa protein. A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development. Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes. Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells.
References:
1. Cirillo, N. et al. (2008) Journal of cellular biochemistry 103, 598-606. PMID: 17559062
2. Xu, T. et al. (2024) Kidney international 105, 1035-1048. PMID: 3839541
3. Park, J. et al. (2018) Stem cell reports 11, 115-127. PMID: 29910125
4. Ebert, LM. et al. (2016) Angiogenesis 19, 463-86. PMID: 27338829
5. Overmiller, AM. et al. (2016) Oncotarget 7, 37536-37555. PMID: 26918609 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Anti-Human DSG2 Antibody (3D3)
Datasheet
