Anti-Human MICA/B Antibody (SAA0346)
- Catalog number: FC10698
- Availability: In Stock
$191.00
- Ex Tax: $191.00
- Description: Anti-Human MICA/B Antibody (SAA0346) [SAA0346] (FC10698) is a human monoclonal antibody detecting MICA in Blocking, ELISA, FCM. Suitable for Human.
Highlights:
• Multi-Application — Validated across multiple applications.
• Flow Cytometry — Validated for flow cytometry applications. - Model: HS894207
- Name: Anti-Human MICA/B Antibody (SAA0346)
- Host species: Human
- Isotype: IgG1, kappa
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4.
- Concentration: 2.4 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: Blocking, ELISA, FCM
- Target: MHC class I polypeptide-related sequence A, MIC-A, MICA, PERB11.1, MHC class I polypeptide-related sequence B, MIC-B, MICB, PERB11.2
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: MHC class I polypeptide-related sequence A (MICA/MICB) is a ~42 kDa protein. Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8 alphabeta T-cells. Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production.
References:
1. Steinle, A. et al. (2001) Immunogenetics 53, 279-87. PMID: 11491531
2. Sutherland, CL. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 671-9. PMID: 1177796
3. Bauer, S. et al. (1999) Science (New York, N.Y.) 285, 727-9. PMID: 10426993 - Note: For research use only.
Images
-
SDS-PAGESDS-PAGE for Anti-Human MICA/B Antibody (SAA0346)
Datasheet
