Anti-Human IL5 Antibody (SAA0374)
- Catalog number: FC10714
- Availability: In Stock
$196.00
- Ex Tax: $196.00
- Description: Anti-Human IL5 Antibody (SAA0374) [SAA0374] (FC10714) is a human monoclonal antibody detecting IL5 in ELISA, FCM. Suitable for Human.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications. - Model: HY218307
- Name: Anti-Human IL5 Antibody (SAA0374)
- Host species: Human
- Isotype: IgG4, kappa
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 0.09% Sodium azide.
- Concentration: 1 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: ELISA, FCM
- Target: IL5, B-cell differentiation factor I, IL-5, T-cell replacing factor, TRF, Eosinophil differentiation factor, Interleukin-5
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Interleukin-5 (IL5) is a ~15 kDa protein. Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Also acts on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively. IL5 is the therapeutic target of mepolizumab (Nucala).
References:
1. Clutterbuck, EJ. et al. (1989) Blood 73, 1504-12. PMID: 2653458
2. Ochiai, K. et al. (1997) Clinical and experimental immunology 107, 198-204. PMID: 9010276
3. Tavernier, J. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 7041-5. PMID: 1495999
4. Kusano, S. et al. (2012) Protein science : a publication of the Protein Society 21, 850-64. PMID: 22528658
5. Alam, R. et al. (1995) International archives of allergy and immunology 107, 226-7. PMID: 7613138 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Anti-Human IL5 Antibody (SAA0374)
Datasheet
