Anti-Human CD85j/LILRB1/ILT2 Antibody (SAA0402)
- Catalog number: FC10744
- Availability: In Stock
$191.00
- Ex Tax: $191.00
- Description: Anti-Human CD85j/LILRB1/ILT2 Antibody (SAA0402) [SAA0402] (FC10744) is a mouse monoclonal antibody detecting LILRB1 in ELISA, FCM. Suitable for Human.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications. - Model: HV631107
- Name: Anti-Human CD85j/LILRB1/ILT2 Antibody (SAA0402)
- Host species: Mouse
- Isotype: IgG2a, kappa
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 0.09% Sodium azide.
- Concentration: 1 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: ELISA, FCM
- Target: LIR1, Immunoglobulin-like transcript 2, MIR7, CD85 antigen-like family member J, Monocyte/macrophage immunoglobulin-like receptor 7, ILT-2, Leukocyte immunoglobulin-like receptor subfamily B member 1, LIR-1, CD85j, ILT2, LILRB1, MIR-7, Leukocyte immunoglobulin-like receptor 1
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Leukocyte immunoglobulin-like receptor subfamily B member 1 (CD85j/LILRB1) is a ~70 kDa protein. Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis.
References:
1. Shiroishi, M. et al. (2006) The Journal of biological chemistry 281, 10439-47. PMID: 16455647
2. Dulberger, CL. et al. (2017) Immunity 46, 1018-1029.e7. PMID: 28636952
3. Bellón, T. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 3351-9. PMID: 11907092
4. Cosman, D. et al. (1997) Immunity 7, 273-82. PMID: 9285411
5. Fanger, NA. et al. (1998) European journal of immunology 28, 3423-34. PMID: 9842885
6. Li, C. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 5767-72. PMID: 19304799
7. Fu, B. et al. (2017) Immunity 47, 1100-1113.e6. PMID: 29262349
8. Naji, A. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 192, 1536-46. PMID: 24453251 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Anti-Human CD85j/LILRB1/ILT2 Antibody (SAA0402)
