Anti-Human GDF11/BMP11 Antibody (SAA0431)
- Catalog number: FC10769
- Availability: In Stock
$196.00
- Ex Tax: $196.00
- Description: Anti-Human GDF11/BMP11 Antibody (SAA0431) [SAA0431] (FC10769) is a mouse monoclonal antibody detecting GDF11 in ELISA, FCM. Suitable for Human.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications. - Model: HF869207
- Name: Anti-Human GDF11/BMP11 Antibody (SAA0431)
- Host species: Mouse
- Isotype: IgG2a, kappa
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 0.09% Sodium azide.
- Concentration: 1 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: ELISA, FCM
- Target: GDF11, BMP-11, BMP11, Growth/differentiation factor 11, GDF-11, Bone morphogenetic protein 11
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Growth/differentiation factor 11 (GDF11/BMP11) is a ~45 kDa protein. Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3.
References:
1. Cox, TC. et al. (2019) Human mutation 40, 1813-1825. PMID: 31215115
2. Walker, RG. et al. (2017) BMC biology 15, 19. PMID: 28257634 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Anti-Human GDF11/BMP11 Antibody (SAA0431)
