Anti-Human BAG3 Antibody (SAA0529)
- Catalog number: FC10826
- Availability: In Stock
$163.00
- Ex Tax: $163.00
- Description: Anti-Human BAG3 Antibody (SAA0529) [SAA0529] (FC10826) is a human monoclonal antibody detecting BAG3 in ELISA, FCM. Suitable for Human.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications. - Model: HF640107
- Name: Anti-Human BAG3 Antibody (SAA0529)
- Host species: Human
- Isotype: IgG2a, kappa
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 0.09% Sodium azide.
- Concentration: 1 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: ELISA, FCM
- Target: Docking protein CAIR-1, BAG3, Bcl-2-associated athanogene 3, BAG family molecular chaperone regulator 3, Bcl-2-binding protein Bis, BAG-3, BIS
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: BAG family molecular chaperone regulator 3 (BAG3) is a ~61 kDa protein. Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release. Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD).
References:
1. Rauch, JN. et al. (2017) Journal of molecular biology 429, 128-141. PMID: 27884606
2. Meister-Broekema, M. et al. (2018) Nature communications 9, 5342. PMID: 30559338
3. Rauch, JN. et al. (2016) The Journal of biological chemistry 291, 19848-57. PMID: 27474739
4. Takayama, S. et al. (1999) The Journal of biological chemistry 274, 781-6. PMID: 9873016
5. Lee, JH. et al. (1999) Oncogene 18, 6183-90. PMID: 10597216
6. Jin, YH. et al. (2015) Biochemical and biophysical research communications 464, 561-7. PMID: 26159920 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Anti-Human BAG3 Antibody (SAA0529)
Datasheet
