Anti-Human CD11a/ITGAL Antibody (HB 9579)
- Catalog number: FC10912
- Availability: In Stock
$191.00
- Ex Tax: $191.00
- Description: Anti-Human CD11a/ITGAL Antibody (HB 9579) [HB 9579] (FC10912) is a mouse monoclonal antibody detecting CD11A in FCM. Suitable for Human.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications. - Model: HB805307
- Name: Anti-Human CD11a/ITGAL Antibody (HB 9579)
- Host species: Mouse
- Isotype: IgG1, kappa
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 0.09% Sodium azide.
- Concentration: 1 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: FCM
- Target: CD11A, Leukocyte function-associated molecule 1 alpha chain, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, CD11 antigen-like family member A, CD11a, ITGAL, Integrin alpha-L
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Integrin alpha-L (CD11a/ITGAL) is a ~128 kDa protein. Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity.
References:
1. Hermand, P. et al. (2000) The Journal of biological chemistry 275, 26002-10. PMID: 1084618
2. Shimaoka, M. et al. (2003) Cell 112, 99-111. PMID: 12526797
3. de Fougerolles, AR. et al. (1991) The Journal of experimental medicine 174, 253-67. PMID: 1676048
4. Dustin, ML. et al. (1986) Journal of immunology (Baltimore, Md. : 1950) 137, 245-54. PMID: 3086451
5. Ostermann, G. et al. (2002) Nature immunology 3, 151-8. PMID: 11812992
6. Fraemohs, L. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 6259-64. PMID: 15528364
7. Swaim, CD. et al. (2017) Molecular cell 68, 581-590.e5. PMID: 29100055
8. Barber, DF. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 3653-9. PMID: 1535611
9. Lacouture, C. et al. (2024) Nature communications 15, 407. PMID: 38195629
10. Kristóf, E. et al. (2013) Apoptosis : an international journal on programmed cell death 18, 1235-51. PMID: 23775590 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Anti-Human CD11a/ITGAL Antibody (HB 9579)
