Anti-Human CD262/TNFRSF10B/TRAIL-R2 Antibody (SAA1413)
- Catalog number: FC10919
- Availability: In Stock
$191.00
- Ex Tax: $191.00
- Description: Anti-Human CD262/TNFRSF10B/TRAIL-R2 Antibody (SAA1413) [SAA1413] (FC10919) is a mouse monoclonal antibody detecting TRAIL-R2 in FCM. Suitable for Human.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications. - Model: HT348307
- Name: Anti-Human CD262/TNFRSF10B/TRAIL-R2 Antibody (SAA1413)
- Host species: Mouse
- Isotype: IgG2a, lambda
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 0.09% Sodium azide.
- Concentration: 1 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: FCM
- Target: TRAILR2, TRAIL-R2, Death receptor 5, CD262, DR5, Tumor necrosis factor receptor superfamily member 10B, ZTNFR9, TRAIL receptor 2, TRICK2, TNFRSF10B, KILLER, TNF-related apoptosis-inducing ligand receptor 2
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Tumor necrosis factor receptor superfamily member 10B (CD262/TRAIL-R2) is a ~47 kDa protein. Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
References:
1. Hymowitz, SG. et al. (1999) Molecular cell 4, 563-71. PMID: 10549288 - Note: For research use only.
Images
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BioactivitySEC-HPLC detection for Anti-Human CD262/TNFRSF10B/TRAIL-R2 Antibody (ABS1916).
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Flow CytoMetryFlow-cytometry using anti-human CD262 antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an anti-human CD262 monoclonal antibody (Catalog: HT348307) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Mouse IgG H&L Polyclonal Antibody, FITC (abinScience: MF690414) and cells analysed on a NovoCyte Flow Cytometer.
