Anti-Human VIPR1/VPAC1 Antibody (23A11)
- Catalog number: FC10995
- Availability: In Stock
$191.00
- Ex Tax: $191.00
- Description: Anti-Human VIPR1/VPAC1 Antibody (23A11) [23A11] (FC10995) is a mouse monoclonal antibody detecting VIPR1 in FCM, SPR, WB. Suitable for Human.
Highlights:
• Multi-Application — Validated across multiple applications.
• Flow Cytometry — Validated for flow cytometry applications. - Model: HB111107
- Name: Anti-Human VIPR1/VPAC1 Antibody (23A11)
- Host species: Mouse
- Isotype: IgG2a, kappa
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 0.09% Sodium azide.
- Concentration: 1 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: FCM, SPR, WB
- Target: VIP-R-1, PACAP-R2, VIPR1, PACAP-R-2, Pituitary adenylate cyclase-activating polypeptide type II receptor, PACAP type II receptor, VPAC1, Vasoactive intestinal polypeptide receptor 1
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Vasoactive intestinal polypeptide receptor 1 (VIPR1/VPAC1) is a ~51 kDa protein. G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of ligand affinity VIP = PACAP27 > PACAP38. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway.
References:
1. Xu, Y. et al. (2022) Nature communications 13, 2272. PMID: 35477937
2. Piper, SJ. et al. (2022) Nature communications 13, 7013. PMID: 36385145
3. Couvineau, A. et al. (1994) Biochemical and biophysical research communications 200, 769-76. PMID: 8179610 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Anti-Human VIPR1/VPAC1 Antibody (23A11)
