Anti-Human CLDN1/Claudin-1 Antibody (6F6C3)
- Catalog number: FC11007
- Availability: In Stock
$191.00
- Ex Tax: $191.00
- Description: Anti-Human CLDN1/Claudin-1 Antibody (6F6C3) [6F6C3] (FC11007) is a mouse monoclonal antibody detecting Claudin 1 in ELISA, FCM. Suitable for Human.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications. - Model: HF976107
- Name: Anti-Human CLDN1/Claudin-1 Antibody (6F6C3)
- Host species: Mouse
- Isotype: IgG2a, kappa
- Conjugation: Unconjugated
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4.
- Concentration: 0.79 mg/ml
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: ELISA, FCM
- Target: CLDN1, Senescence-associated epithelial membrane protein, CLD1, Claudin-1, SEMP1
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Claudin-1 (CLDN1) is a ~22 kDa protein. Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions.
References:
1. Kirschner, N. et al. (2013) The Journal of investigative dermatology 133, 1161-9. PMID: 23407391 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Anti-Human CLDN1/Claudin-1 Antibody (6F6C3)
