Anti-Human NPR1/NPR-A Reference Antibody (REGN5381)
- Catalog number: BS12282
- Availability: In Stock
$370.00
- Ex Tax: $370.00
Description: Anti-Human NPR1/NPR-A Antibody (REGN5381) (BS12282) is a research-grade recombinant antibody targeting ANP-A. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG
Species reactivity: Human,Crab-eatingmacaque,Dog
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: ANP-A,AtrialnatriureticpeptidereceptortypeA,GuanylatecyclaseA,NPR1,NPR-A,ANPRA,GC-A,ANPR-A,Atrialnatriureticpeptidereceptor1
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Atrial natriuretic peptide receptor 1 (NPR1/NPR-A) is a ~118 kDa protein. Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Plays an essential role in the regulation of endothelial cell senescence and vascular aging. Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis.
References:
1. Liu, S. et al. (2025) Nature structural & molecular biology 32, 469-478. PMID: 39543315
2. Long, C. et al. (2022) Aging cell 21, e13699. PMID: 36016499
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG
Species reactivity: Human,Crab-eatingmacaque,Dog
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: ANP-A,AtrialnatriureticpeptidereceptortypeA,GuanylatecyclaseA,NPR1,NPR-A,ANPRA,GC-A,ANPR-A,Atrialnatriureticpeptidereceptor1
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Atrial natriuretic peptide receptor 1 (NPR1/NPR-A) is a ~118 kDa protein. Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Plays an essential role in the regulation of endothelial cell senescence and vascular aging. Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis.
References:
1. Liu, S. et al. (2025) Nature structural & molecular biology 32, 469-478. PMID: 39543315
2. Long, C. et al. (2022) Aging cell 21, e13699. PMID: 36016499
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
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SDS-PAGESDS-PAGE for Research Grade Anti-Human NPR1/NPR-A Antibody (REGN5381)
