Anti-Human EMMPRIN/CD147 Reference Antibody (Meplazumab, RUO)

Description: Meplazumab (BS10189) is a research-grade recombinant antibody targeting CD147. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Humanized
Isotype: IgG1-kappaorIGG2
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1.8mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: Hepatoma-associatedantigen,BSG,HAb18G,5F7,TCSF,OKbloodgroupantigen,Collagenasestimulatoryfactor,CD147,LeukocyteactivationantigenM6,Basigin,Extracellularmatrixmetalloproteinaseinducer,EMMPRIN,Tumorcell-derivedcollagenasestimulatoryfactor
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names:
Background: Basigin (CD147/BSG) is a ~42 kDa protein. Essential for normal retinal maturation and development. Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors. In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors. May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes.
References:
1. Aït-Ali, N. et al. (2015) Cell 161, 817-32. PMID: 25957687
2. Redzic, JS. et al. (2011) Journal of molecular biology 411, 68-82. PMID: 21620857
Note: For research use only. Not suitable for clinical or therapeutic use.