Anti-Human CD21/CR2 Antibody (Ab652)
- Catalog number: FC15112
- Availability: In Stock
$191.00
- Ex Tax: $191.00
- Description: Anti-Human CD21/CR2 Antibody (Ab652) [Ab652] (FC15112) is a mouse monoclonal antibody detecting CD21 in ELISA, FCM. Suitable for Human.
Highlights:
• Flow Cytometry — Validated for flow cytometry applications. - Model: HB939307
- Name: Anti-Human CD21/CR2 Antibody (Ab652)
- Host species: Mouse
- Isotype: IgG2a, kappa
- Species reactivity: Human
- Form: Liquid
- Storage buffer: 0.01M PBS, pH 7.4, 0.09% Sodium azide.
- Purity: >95% as determined by SDS-PAGE.
- Clonality: Monoclonal
- Applications: ELISA, FCM
- Target: Cr2, Complement C3d receptor, C3DR, Epstein-Barr virus receptor, Complement receptor type 2, CR2, EBV receptor, CD21
- Purification: Protein A/G purified from cell culture supernatant.
- Endotoxin level: Please contact with the lab for this information.
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Background: Complement receptor type 2 (CD21/CR2) is a ~112 kDa protein. Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells. This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling. Also induces specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner.
References:
1. Delcayre, AX. et al. (1991) The EMBO journal 10, 919-26. PMID: 1849076
2. van den Elsen, JM. et al. (2011) Science (New York, N.Y.) 332, 608-11. PMID: 21527715
3. Barel, M. et al. (1995) Molecular immunology 32, 389-97. PMID: 7753047
4. Bradbury, LE. et al. (1992) Journal of immunology (Baltimore, Md. : 1950) 149, 2841-50. PMID: 1383329
5. Franco, A. et al. (2018) International immunology 30, 569-578. PMID: 30107486
6. Barel, M. et al. (2003) European journal of immunology 33, 2557-66. PMID: 12938232
7. Aubry, JP. et al. (1992) Nature 358, 505-7. PMID: 1386409 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Anti-Human CD21/CR2 Antibody (Ab652)
Datasheet
