Anti-Human TRAILR1/TNFRSF10A Reference Antibody (Mapatumumab, RUO)
- Catalog number: BS10232
- Availability: In Stock
$176.00
- Ex Tax: $176.00
Description: Mapatumumab (BS10232) is a research-grade recombinant antibody targeting CD261. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG1-nd
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: TNF-relatedapoptosis-inducingligandreceptor1,APO2,Deathreceptor4,TRAILreceptor1,TRAIL-R1,CD261,DR4,TRAILR1,TNFRSF10A,Tumornecrosisfactorreceptorsuperfamilymember10A
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: HGS-ETR1,TRM-1,CAS:658052-09-6
Background: Tumor necrosis factor receptor superfamily member 10A (CD261/TNFRSF10A) is a ~50 kDa protein. Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
References:
1. Ramamurthy, V. et al. (2015) Acta crystallographica. Section F, Structural biology communications 71, 1273-81. PMID: 26457518
2. Chyuan, IT. et al. (2024) Journal of biomedical science 31, 33. PMID: 38532423
3. Rossin, A. et al. (2009) The Biochemical journal 419, 185-92, 2 p following 192. PMID: 19090789
4. Chaudhary, PM. et al. (1997) Immunity 7, 821-30. PMID: 9430227
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Human
Isotype: IgG1-nd
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: TNF-relatedapoptosis-inducingligandreceptor1,APO2,Deathreceptor4,TRAILreceptor1,TRAIL-R1,CD261,DR4,TRAILR1,TNFRSF10A,Tumornecrosisfactorreceptorsuperfamilymember10A
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: HGS-ETR1,TRM-1,CAS:658052-09-6
Background: Tumor necrosis factor receptor superfamily member 10A (CD261/TNFRSF10A) is a ~50 kDa protein. Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
References:
1. Ramamurthy, V. et al. (2015) Acta crystallographica. Section F, Structural biology communications 71, 1273-81. PMID: 26457518
2. Chyuan, IT. et al. (2024) Journal of biomedical science 31, 33. PMID: 38532423
3. Rossin, A. et al. (2009) The Biochemical journal 419, 185-92, 2 p following 192. PMID: 19090789
4. Chaudhary, PM. et al. (1997) Immunity 7, 821-30. PMID: 9430227
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
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BioactivitySEC-HPLC detection for Research Grade Mapatumumab.
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SDS-PAGESDS-PAGE for Research Grade Mapatumumab.
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Western blotWestern blot analysis was performed using anti-CD261/TNFRSF10A monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD261/TNFRSF10A (Catalog No: PH13570)
Lane 2: negative control
