Anti-Human TIM-3 Reference Antibody (Sabatolimab, RUO)
- Catalog number: BS10297
- Availability: In Stock
$176.00
- Ex Tax: $176.00
Description: Sabatolimab (BS10297) is a research-grade recombinant antibody targeting CD366. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Humanized
Isotype: IgG4-kappa
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1.56mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: T-cellimmunoglobulinmucinreceptor3,HAVcr-2,TIMD-3,T-cellmembraneprotein3,HAVCR2,HepatitisAviruscellularreceptor2,CD366,TIMD3,TIM-3,TIM3,T-cellimmunoglobulinandmucindomain-containingprotein3
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: MBG-453,CAS:2252262-24-9
Background: Hepatitis A virus cellular receptor 2 (CD366/TIM-3) is a ~33 kDa protein. Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance.
References:
1. Gorman, JV. et al. (2014) Immunologic research 59, 56-65. PMID: 24825777
2. Monney, L. et al. (2002) Nature 415, 536-41. PMID: 11823861
3. Sánchez-Fueyo, A. et al. (2003) Nature immunology 4, 1093-101. PMID: 14556005
4. Clayton, KL. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 192, 782-91. PMID: 24337741
5. Tomkowicz, B. et al. (2015) PloS one 10, e0140694. PMID: 26492563
6. Gautron, AS. et al. (2014) European journal of immunology 44, 2703-2711. PMID: 24838857
7. Zhu, C. et al. (2005) Nature immunology 6, 1245-52. PMID: 1628692
8. Leitner, J. et al. (2013) PLoS pathogens 9, e1003253. PMID: 23555261
9. Gleason, MK. et al. (2012) Blood 119, 3064-72. PMID: 22323453
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Humanized
Isotype: IgG4-kappa
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1.56mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: T-cellimmunoglobulinmucinreceptor3,HAVcr-2,TIMD-3,T-cellmembraneprotein3,HAVCR2,HepatitisAviruscellularreceptor2,CD366,TIMD3,TIM-3,TIM3,T-cellimmunoglobulinandmucindomain-containingprotein3
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: MBG-453,CAS:2252262-24-9
Background: Hepatitis A virus cellular receptor 2 (CD366/TIM-3) is a ~33 kDa protein. Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance.
References:
1. Gorman, JV. et al. (2014) Immunologic research 59, 56-65. PMID: 24825777
2. Monney, L. et al. (2002) Nature 415, 536-41. PMID: 11823861
3. Sánchez-Fueyo, A. et al. (2003) Nature immunology 4, 1093-101. PMID: 14556005
4. Clayton, KL. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 192, 782-91. PMID: 24337741
5. Tomkowicz, B. et al. (2015) PloS one 10, e0140694. PMID: 26492563
6. Gautron, AS. et al. (2014) European journal of immunology 44, 2703-2711. PMID: 24838857
7. Zhu, C. et al. (2005) Nature immunology 6, 1245-52. PMID: 1628692
8. Leitner, J. et al. (2013) PLoS pathogens 9, e1003253. PMID: 23555261
9. Gleason, MK. et al. (2012) Blood 119, 3064-72. PMID: 22323453
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
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BioactivitySEC-HPLC detection for Research Grade Sabatolimab.
