Anti-Human DLL4 Reference Antibody (Demcizumab, RUO)
- Catalog number: BS10378
- Availability: In Stock
$176.00
- Ex Tax: $176.00
Description: Demcizumab (BS10378) is a research-grade recombinant antibody targeting Delta-like protein 4. Produced in mammalian cells with native-like glycosylation.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Humanized
Isotype: IgG2-kappa
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: Delta-likeprotein4,DrosophilaDeltahomolog4,Delta4,DLL4
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: OMP-21M18,CAS:1243262-17-0
Background: Delta-like protein 4 (DLL4) is a ~74 kDa protein. Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types.
References:
1. Yoneya, T. et al. (2001) Journal of biochemistry 129, 27-34. PMID: 11134954
2. Brütsch, R. et al. (2010) Circulation research 107, 592-601. PMID: 20616313
3. Del Barrio, MG. et al. (2007) Development (Cambridge, England) 134, 3427-36. PMID: 17728344
Note: For research use only. Not suitable for clinical or therapeutic use.
Highlights:
• Research Grade — For PK/PD studies, assay development, and ADA research.
• Native Glycosylation — Mammalian expression ensures native-like patterns.
Host species: Humanized
Isotype: IgG2-kappa
Species reactivity: Human
Immunogen:
Form: Liquid
Storage instructions:
Storage buffer: 0.01M PBS, pH7.4.
Concentration: 1mg/ml
Purity: >95% as determined by SDS-PAGE.
Clonality: Monoclonal
Applications: Research Grade Biosimilar
Target: Delta-likeprotein4,DrosophilaDeltahomolog4,Delta4,DLL4
Purification: Protein A/G purified from cell culture supernatant.
Endotoxin level: <1EU/mg, determined by LAL gel clotting assay
Expression system: Mammalian Cells
Stability and Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names: OMP-21M18,CAS:1243262-17-0
Background: Delta-like protein 4 (DLL4) is a ~74 kDa protein. Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types.
References:
1. Yoneya, T. et al. (2001) Journal of biochemistry 129, 27-34. PMID: 11134954
2. Brütsch, R. et al. (2010) Circulation research 107, 592-601. PMID: 20616313
3. Del Barrio, MG. et al. (2007) Development (Cambridge, England) 134, 3427-36. PMID: 17728344
Note: For research use only. Not suitable for clinical or therapeutic use.
Images
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SEC-HPLCSEC-HPLC detection for Research Grade Demcizumab.
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SDS-PAGESDS-PAGE for Research Grade Demcizumab.
