Human ADCY7 Recombinant Protein (N-His)
- Catalog number: PH11751
- Availability: In Stock
$211.00
- Ex Tax: $211.00
- Description: Recombinant Human ADCY7 Protein, N-His (PH11751) expressed in E. coli, spanning Pro854-Asn1080. Purity: >90% by SDS-PAGE.
Highlights:
• His-Tagged — N-terminal 6×His tag for IMAC purification.
• E. coli Expression — High-yield, cost-effective production.
• High Purity — >90% purity verified by SDS-PAGE. - Form: Lyophilized
- Storage buffer: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
- Purity: >90% as determined by SDS-PAGE.
- Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
- Endotoxin level: Please contact with the lab for this information.
- Expression system: E. coli
- Protein length: Pro854-Asn1080
- Predicted molecular weight: 27.38 kDa
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Reconstitution: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
- Alternative Names: Adenylate cyclase type VII, ADCY7, ATP pyrophosphate-lyase 7, Adenylate cyclase type 7, Adenylyl cyclase 7, KIAA0037
- Species: Homo sapiens (Human)
- Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
- Background: Adenylate cyclase type 7 (ADCY7) is a ~120 kDa protein. Adenylate cyclase that mediates formation of both cyclic AMP (cAMP) and cyclic di-AMP (c-di-AMP). Acts as a key mediator of G protein-coupled receptor signaling by catalyzing the formation of cAMP downstream of G protein-coupled receptors. Functions in G protein-coupled receptor signaling cascades activated by thrombin, sphingosine 1-phosphate, dopamine and anaphylatoxin C5a. Mediates regulation of cAMP synthesis through synergistic action of the G alpha protein G(s) (GNAS) with G(13) (GNA13). Also involved in inflammation by acting as a diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into c-di-AMP.
References:
1. Yan, SZ. et al. (2001) The Journal of biological chemistry 276, 8500-6. PMID: 11113152
2. Jiang, LI. et al. (2008) The Journal of biological chemistry 283, 23429-39. PMID: 1854153
3. Jiang, LI. et al. (2013) Molecular pharmacology 83, 587-93. PMID: 23229509
4. Ehrlich, AT. et al. (2013) Molecular pharmacology 84, 476-86. PMID: 23842570 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Recombinant Human ADCY7 Protein, N-His
