Human CD158d/KIR2DL4 Recombinant Protein (C-His)
- Catalog number: PH13709
- Availability: In Stock
$298.00
- Ex Tax: $298.00
- Description: Recombinant Human CD158d/KIR2DL4 Protein, C-His (PH13709) expressed in Mammalian Cells, spanning Met1-His242.
Highlights:
• His-Tagged — N-terminal 6×His tag for IMAC purification.
• Mammalian Expression — Proper folding and native glycosylation.
• High Purity — >90% purity verified by SDS-PAGE. - Form: Lyophilized
- Storage buffer: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
- Purity: >90% as determined by SDS-PAGE.
- Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
- Endotoxin level: Please contact with the lab for this information.
- Expression system: Mammalian Cells
- Protein length: Met1-His242
- Predicted molecular weight: 27.52 kDa
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Reconstitution: Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
- Alternative Names: KIR2DL4, KIR-103AS, KIR103AS, CD158d, CD158 antigen-like family member D, CD158D, MHC class I NK cell receptor KIR103AS, Killer cell immunoglobulin-like receptor 2DL4, G9P, Killer cell inhibitory receptor 103AS
- Species: Homo sapiens (Human)
- Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
- Background: Killer cell immunoglobulin-like receptor 2DL4 (CD158d/KIR2DL4) is a ~41 kDa protein. Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy. May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells. Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent pro-inflammatory response.
References:
1. Rajagopalan, S. et al. (2006) PLoS biology 4, e9. PMID: 16366734
2. Rajagopalan, S. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 20596-601. PMID: 23184984
3. Fu, B. et al. (2017) Immunity 47, 1100-1113.e6. PMID: 29262349
4. Rajagopalan, S. et al. (1999) The Journal of experimental medicine 189, 1093-100. PMID: 1019090
5. Rajagopalan, S. et al. (2010) Science signaling 3, ra14. PMID: 20179272 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Recombinant Human CD158d/KIR2DL4 Protein, C-His
