Human CD320 Recombinant Protein (C-Fc)
- Catalog number: PH13719
- Availability: In Stock
$298.00
- Ex Tax: $298.00
- Description: Recombinant Human CD320 Protein, C-Fc (PH13719) expressed in Mammalian Cells, spanning Met1-Gly208.
Highlights:
• Fc Fusion — Enhanced stability with Protein A/G purification compatibility.
• Mammalian Expression — Proper folding and native glycosylation.
• High Purity — >90% purity verified by SDS-PAGE. - Form: Lyophilized
- Storage buffer: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
- Purity: >90% as determined by SDS-PAGE.
- Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
- Endotoxin level: Please contact with the lab for this information.
- Expression system: Mammalian Cells
- Protein length: Met1-Gly208
- Predicted molecular weight: 47.87 kDa
- Stability and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Reconstitution: Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
- Alternative Names: FDC-SM-8D6, FDC-signaling molecule 8D6, CD320, TCblR, 8D6 antigen, 8D6A, Transcobalamin receptor, CD320 antigen
- Species: Homo sapiens (Human)
- Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
- Background: CD320 antigen is a ~28 kDa protein. Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC).
References:
1. Quadros, EV. et al. (2009) Blood 113, 186-92. PMID: 18779389
2. Quadros, EV. et al. (2010) Human mutation 31, 924-9. PMID: 20524213
3. Li, L. et al. (2000) The Journal of experimental medicine 191, 1077-84. PMID: 1072747
4. Zhang, X. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 49-56. PMID: 11418631 - Note: For research use only.
Images
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SDS-PAGESDS-PAGE for Recombinant Human CD320 Protein, C-Fc
